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. 2019 Oct 31;45(1):45–52. doi: 10.3892/ijmm.2019.4388

Figure 2.

Figure 2

High glucose affects SOX6 and miR-342-3p expression in vitro in a dose- and time-dependent manner. (A and B) Expression levels of SOX6 mRNA and miR-342-3p in MCs were detected at the indicated time points (0, 12, 24 and 36 h) by RT-qPCR following culture in high-glucose medium. High glucose upregulated SOX6 and downregulated miR-342-3p expression in a time-dependent manner. (C and D) The expression of SOX6 mRNA and miR-342-3p in MCs was detected at 12 h following treatment with various concentrations of glucose (0, 50, 100 and 200 µM) by RT-qPCR. High glucose upregulated SOX6 and downregulated miR-342-3p expression in a dose-dependent manner. *P<0.05 and **P<0.01. SOX6, SRY-box 6; MCs, mesangial cells.