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. 2019 Nov 4;45(1):103–114. doi: 10.3892/ijmm.2019.4395

Figure 6.

Figure 6

MgTX regulates macrophage polarization via the STAT1/STAT6 pathway. MgTX was administered to M1 phenotype macrophages or M2 phenotype macrophages, respectively, and the expression of phosphorylated STAT1/STAT6 was measured using western blot analysis. (A-C) Data are presented as the relative protein expression against control expression without treatment. The phosphorylated levels of STAT1/STAT6 in M1/M2 phenotype macrophages increased significantly compared with the control group, and p-STAT1 expression was downregulated in M1 phenotype macrophages treated with MgTX. *P<0.05 vs. M1 group; ##P<0.01 vs. control group (N). p-STAT6 was upregulated in M2 phenotype macrophages treated with MgTX. **P<0.05 vs. M2 group; #P<0.05 vs. control group. n=3. MgTX, margatoxin.