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. 2019 Nov 13;45(1):162–174. doi: 10.3892/ijmm.2019.4404

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Copyright: © Wu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of APP overexpression and silencing on the expression levels of EMT-related factors in MDA-MB-231 breast cancer cells. (A) mRNA expression levels of EMT-related genes were detected using RT-qPCR following APP overexpression and silencing in MDA-MB-231 cells. (B) Representative western blotting bands of the protein expression of EMT-related factors. (C) Protein expression levels of EMT-related factors were detected by western blot analysis following APP overexpression and silencing in MDA-MB-231 cells. All experiments were performed in triplicate. Data are presented as the mean ± SD. ^*P<0.05 vs. control. APP, amyloid precursor protein; EMT, epithelial-to-mesenchymal transition; RT-qPCR, reverse transcription-quantitative PCR; MMP, matrix metalloproteinase; shRNA, short hairpin RNA.