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. 2019 Nov 13;45(1):195–209. doi: 10.3892/ijmm.2019.4407

Figure 3.

Figure 3

Rapamycin inhibits the mTOR and endoplasmic reticulum stress pathways in hearts of HF rats at 8 and 12 weeks following MI. (A) Western blot of phospho-ribosomal S6 protein, total ribosomal S6, phospho-Akt and total Akt. (B) Western blot of GRP78, cleavage of caspase-12, phospho-JNK, total JNK and DDIT3. *P<0.05 vs. the corresponding sham group; #P<0.05 vs. the corresponding vehicle group. HF, heart failure; Rap, rapamycin; MI, myocardial infarction; RibS6, ribosomal S6 protein; GRP78, glucose-regulated protein 78 kDa; DDIT3, DNA damage-inducible transcript 3; JNK, c-JUN NH2-terminal kinase.