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. 2019 Nov 11;45(1):175–185. doi: 10.3892/ijmm.2019.4400

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of hypoxia on mast cells and ECM remodeling in rat lungs. (A) The pathological changes of pulmonary vessels in the rat lungs after exposure to hypoxia were examined by hematoxylin and eosin staining (magnification, ×200 and 400). (B) Toluidine blue staining demonstrated increased accumulation of mast cells in the lungs of hypoxic rats (magnification, ×200 and 400). (C and D) The expression of collagen I, collagen III, MMP-9, MMP-13 and TIMP-1 in the lungs of rats after exposure to hypoxia was determined by immunohistochemistry staining (magnification, ×200). ECM, extracellular matrix; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase; N, normoxic; H, hypoxic.