Table I.
Top 20 upregulated and downregulated mRNAs in human fetal lung fibroblasts (HFL-1) cultured in hypoxic conditioned medium from human mast cells (HMC-1) and normoxic controls.
| A, Upregulated mRNAs
| ||
|---|---|---|
| mRNAs | P-value | log2 fold change |
| TNFSF8 | 0.000 | 9.4533 |
| IL36RN | 0.020 | 9.1130 |
| CYP19A1 | 0.000 | 8.5295 |
| BEST3 | 0.001 | 7.0775 |
| IL24 | 0.000 | 7.0084 |
| WTAPP1 | 0.000 | 6.7566 |
| STC1 | 0.000 | 6.6111 |
| ESM1 | 0.002 | 6.6003 |
| CCL3L3 | 0.002 | 6.5711 |
| MMP10 | 0.002 | 6.5556 |
| IL36B | 0.002 | 6.5535 |
| THBD | 0.000 | 6.4407 |
| CSF2 | 0.026 | 6.3719 |
| DCSTAMP | 0.000 | 6.3002 |
| IL1B | 0.000 | 6.2982 |
| SHISA2 | 0.005 | 6.2159 |
| LCE1C | 0.000 | 6.1842 |
| EREG | 0.000 | 6.1640 |
| PTGS2 | 0.000 | 6.1336 |
| SERPINB2/10 | 0.000 | 6.0740 |
|
| ||
| B, Downregulated mRNAs | ||
|
| ||
| mRNAs | P-value | log2 fold change |
|
| ||
| MUC19 | 0.038 − | 8.1010 |
| USH2A | 0.000 − | 7.3792 |
| TACR3 | 0.000 − | 7.3221 |
| ADH1B | 0.000 | −7.0604 |
| RSPO2 | 0.000 | −6.8458 |
| CDSN | 0.000 | −6.6503 |
| ITIH5 | 0.000 | −6.6445 |
| SMTNL2 | 0.000 | −6.6222 |
| RNU2-52P | 0.000 | −6.5828 |
| PTGDR2 | 0.000 | −6.5349 |
| ASTN1 | 0.000 | −6.5022 |
| SPTB | 0.000 | −6.4692 |
| OGN | 0.000 | −6.4411 |
| LAD | 0.000 | −6.3950 |
| NFE2 | 0.000 | −6.3828 |
| GPR20 | 0.000 | −6.2826 |
| MUC22 | 0.000 | −6.2617 |
| TMEM37 | 0.000 | −6.2537 |
| ABCA9 | 0.000 | −6.2412 |
| DNAH2 | 0.000 | −6.2343 |