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. 2019 Dec 2;144(6):e20192614. doi: 10.1542/peds.2019-2614

TABLE 2.

Total Cost and Cost per Hospitalization for Bronchiolitis Hospitalization, According to Different Subpopulations, 2003–2016

Cost
2003 2006 2009 2012 2016 Ptrenda
All bronchiolitis hospitalizations, children aged 0–23.9 mo
 Total direct cost (95% CI)b 449 (421–478) 735 (677–793) 641 (588–694) 701 (637–765) 734 (660–809) .42
 Cost per hospitalization, geometric mean (95% CI)c,d 3267 (3188–3345) 3624 (3509–3740) 3479 (3369–3589) 3523 (3378–3669) 4086 (3912–4260) <.001
Sensitivity analyses
 Infants aged 0–11.9 mo
  Total direct cost (95% CI)b 381 (356–405) 639 (587–691) 547 (499–594) 583 (528–639) 599 (540–659) .42
  Cost per hospitalization, geometric mean (95% CI)c,d 3294 (3213–3376) 3696 (3574–3817) 3552 (3434–3670) 3594 (3440–3749) 4212 (4032–4392) <.001
 Bronchiolitis, primary diagnosis
  Total direct cost (95% CI)b 413 (386–439) 636 (585–687) 522 (476–568) 598 (543–652) 596 (534–658) .58
  Cost per hospitalization, geometric mean (95% CI)c,d 3235 (3156–3313) 3563 (3449–3676) 34,06 (3293–3518) 3470 (3324–3618) 3967 (3792–4141) <.001
 Children without pediatric complex chronic conditions
  Total direct cost (95% CI)b 413 (388–439) 613 (570–657) 515 (477–554) 542 (497–587) 517 (469–565) .58
  Cost per hospitalization, geometric mean (95% CI)c,d 3192 (3116–3278) 3465 (3360–3569) 3300 (3201–3398) 3305 (3176–3435) 3749 (3598–3899) <.001
 Bronchiolitis, primary diagnosis, by children aged 0–11.9 mo without pediatric complex chronic conditions
  Total direct cost (95% CI)b 326 (305–347) 467 (433–502) 361 (331–391) 388 (355–422) 339 (308–371) .90
  Cost per hospitalization, geometric mean (95% CI)c,d 3195 (3116–3274) 3471 (3362–3579) 3296 (3189–3402) 3320 (3183–3458) 3724 (3572–3876) <.001
 Children with a pediatric complex chronic condition
  Total direct cost (95% CI)b 36 (33–40) 121 (104–139) 126 (108–144) 159 (149–180) 217 (187–248) .046
  Cost per hospitalization, geometric mean (95% CI)c,d 5069 (4855–5284) 7055 (6634–7476) 6788 (6425–7151) 6871 (6473–7270) 7465 (7050–7880) <.001
Stratification by use of mechanical ventilation
 With mechanical ventilation use
  Total direct cost (95% CI)b 94 (75–113) 114 (95–132) 117 (100–134) 141 (122–161) 195 (163–226) .046
  Cost per hospitalization, geometric mean (95% CI)c,d 10 093 (9053–11 134) 25 212 (22 589–27 834) 25 618 (23 415–27 820) 21 445 (18 493–24 397) 18 525 (15 841–21 208) <.001
  Invasive mechanical ventilation use
  Total direct cost (95% CI)b 77 (59–95) 103 (85–120) 105 (90–121) 118 (101–135) 144 (120–168) .046
  Cost per hospitalization, geometric mean (95% CI)c,d 10 376 (9301–11 450) 29 243 (26 311–32 174) 33 204 (30 390–36 019) 29 671 (23 068–36 275) 36 207 (33 191–39 223) <.001
  Noninvasive mechanical ventilation use
  Total direct cost (95% CI)b 17 (14–20) 11 (8–14) 12 (9–14) 23 (18–29) 51 (36–66) .15
  Cost per hospitalization, geometric mean (95% CI)c,d 9090 (6587–11 594) 14 209 (12 737–15 681) 12 125 (11 082–13 168) 12 595 (11 541–13 648) 11 446 (10 101–12 792) <.001
 Without mechanical ventilation use
  Total direct cost (95% CI)b 440 (412–468) 621 (577–666) 524 (485–564) 560 (512–607) 539 (492–587) .58
  Cost per hospitalization, geometric mean (95% CI)c,d 3242 (3163–3320) 3478 (3373–3583) 3321 (3221–3420) 3337 (3204–3470) 3747 (3597–3897) <.001
Stratification by hospital designation
 Non–children’s hospital
  Total direct cost (95% CI)b 349 (329–370) 519 (482–556) 434 (404–465) 434 (399–469) 405 (367–444) .97
  Cost per hospitalization, geometric mean (95% CI)c,d 3054 (2983–3125) 3304 (3208–3399) 3113 (3034–3193) 3060 (2952–3168) 3412 (3279–3544) <.001
 Children’s hospital
  Total direct cost (95% CI)b 100 (79–121) 216 (170–262) 207 (162–251) 267 (213–322) 329 (264–394) .07
  Cost per hospitalization, geometric mean (95% CI)c,d 4696 (4421–4970) 5619 (5111–6127) 5883 (5406–6360) 5805 (5146–6464) 6506 (5924–7088) <.001
a

P value for trend test. Cost was adjusted for inflation.

b

Data are presented as US dollars (million). Cost was adjusted for inflation.

c

Data are presented as US dollars. Cost was adjusted for inflation.

d

P value for trend test in unweighted samples because of the discontinuity in hospital identification codes between 2009 and 2012. Cost was adjusted for inflation.