Figure 4.

The effect of FTS on survival of newborn neurons in Aβ_1-42-mice. (A) Immunohistochemistry of 1-, 14-, and 28-day-old BrdU⁺ cells in control mice (control), FTS-treated control mice (FTS), Aβ_1-42-mice (Aβ_1-42), and FTS-treated Aβ_1-42-mice (Aβ_1-42/FTS). Scale bar = 50 mm. (B) Comparison of the number of 1-day-old BrdU⁺ cells. #p < 0.05 and ##p < 0.01 vs control mice; *p < 0.05 vs Aβ_1-42-mice. (C) Dose-dependency of FTS-protected 14-day-old BrdU⁺ cells in Aβ_1-42-mice. *p < 0.05 and **P < 0.01 vs FTS-treated group. (D) Immunofluorescence of 28-day-old BrdU⁺/NeuN⁺ cells. Representative pictures of BrdU⁺/NeuN⁺ cells. Scale bar = 25 mm. (E) Comparison of the number of 28-day-old BrdU⁺/NeuN⁺ cells. ##p < 0.01 vs control mice; **p < 0.01 vs Aβ_1-42-mice.

Abbreviations: FTS, S-trans, trans-farnesylthiosalicylic; vs, versus; BrdU, 5-bromo-2-deoxyuridine.