Table 5.

Adverse Events

Adverse Events	No. of Patients (%)			P
Total	B+PP (n=26)	PP (n=45)
Any grade	40 (56.3)	19 (73.1)	21 (46.7)	0.031
Hematologic	19 (26.8)	8 (30.7)	11 (24.4)
Gastrointestinal	27 (38.0)	13 (50.0)	14 (31.1)
Hypertension	2 (2.8)	2 (7.7)	0 (0)
Thrombosis	0 (0)	0 (0)	0 (0)
Hemorrhage	0 (0)	0 (0)	0 (0)
Proteinuria	0 (0)	0 (0)	0 (0)
Grade ≥3	4 (5.6)	2 (7.7)	2 (4.4)	0.970
Hematologic	3 (4.2)	2 (7.7)	1 (2.2)
Gastrointestinal	1 (1.4)	0 (0)	1 (2.2)
Hypertension	0 (0)	0 (0)	0 (0)
AE leading to drug death	0 (0)	0 (0)	0 (0)
AE leading to drug withdrawal	1 (1.4)	1 (3.8)	0 (0)

Abbreviations: B+PP, bevacizumab plus pemetrexed-platinum; PP, pemetrexed-platinum.