Table 1.
Characteristics of HTLV‐1 asymptomatic carriers and indolent ATL cases
|
G1 (n = 21) |
G2 (n = 17) |
G3 (n = 19) |
G4 (n = 14) |
P‐value | |
|---|---|---|---|---|---|
| Age, median (range) | 52 (31‐70) | 54 (32‐66) | 54 (44‐72) | 51 (43‐68) | 0.84 |
| <40 years old (%) | 2 (9.5) | 3 (17.6) | 0 | 0 | 0.14 |
| ≥40 years old (%) | 19 (90.5) | 14 (82.4) | 19 (100) | 14 (100) | |
| Female (%) | 15 (71.4) | 11 (64.7) | 10 (52.6) | 9 (64.3) | 0.68 |
| Abnormal lymphocytes (%), median (range) | 0.5 (0‐4.0) | 2.0 (0.5‐40.0) | 5.0 (1.3‐8.3) | 19.1 (3.7‐60.5) | <0.01 |
| sIL‐2R (U/mL), median (range) | 291 (181‐637) | 360 (220‐699) | 550 (272‐1310) | 1041 (483‐2490) | <0.01 |
| ≤1000 (%) | 21 (100) | 16 (94.1) | 16 (84.2) | 7 (50.0) | <0.01 |
| >1000, ≤6000 (%) | 0 | 0 | 2 (10.5) | 7 (50.0) | |
| Not evaluated (%) | 0 | 1 (5.9) | 1 (5.3) | 0 | |
| PVL (copies/100 PBMC), median (range) | 0.60 (0.01‐5.25) | 6.90 (2.56‐12.67) | 11.60 (5.51‐29.80) | 39.97 (10.93‐86.97) | <0.01 |
| <4 (%) | 20 (95.2) | 2 (11.8) | 0 | 0 | <0.01 |
| ≥4 (%) | 1 (4.8) | 13 (76.5) | 15 (78.9) | 11 (78.6) | |
| Not evaluated (%) | 0 | 2 (11.8) | 4 (21.1) | 3 (21.4) | |
| Initial diagnosis | <0.01 | ||||
| Asymptomatic carriers (%) | 21 (100) | 17 (100) | 9 (47.4) | 2 (14.3) | |
| Smoldering‐type ATL (%) | 0 | 0 | 9 (47.4) | 6 (42.9) | |
| Chronic‐type ATL (%) | 0 | 0 | 1 (5.3) | 6 (42.9) |
Abbreviations: ATL, adult T‐cell leukemia/lymphoma; PBMC, peripheral blood mononuclear cells; PVL, proviral load; sIL‐2R, soluble interleukin‐2 receptor.