Table 3. Association between comorbidity and overall survival, stratified by cancer sub-site and HPV status.
| Model | Comorbidity | All sites | Oral cavity | Oropharynx | Larynx | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All cases | HPV-negative | HPV-positive | |||||||||||
| HR (95%CI) |
p-trend | HR (95%CI) |
p-trend | HR (95%CI) |
p-trend | HR (95%CI) |
p-trend | HR (95%CI) |
p-trend | HR (95%CI) |
p-trend | ||
| Minimally adjusted* | Mild | 1.5 (1.2, 2.0) | <.001 | 1.5 (1.0, 2.2) | <.001 | 1.8 (1.3-2.6) | <.001 | 2.2 (1.2, 3.6) | .02 | 1.1 (0.6-2.0) | .05 | 1.2 (0.8, 1.9) | .003 |
| Moderate | 2.0 (1.5, 2.6) | 1.8 (1.1, 2.7) | 2.5 (1.6, 3.7) | 2.0 (1.1, 3.7) | 2.0 (1.1, 3.8) | 1.8 (1.1, 2.9) | |||||||
| Severe | 3.8 (2.6, 5.4) | 4.6 (2.8, 7.6) | 3.3 (1.6, 6.7) | 2.6 (1.3, 5.5) | |||||||||
| Clinical model† | Mild | 1.5 (1.2, 1.9) | <.001 | 1.3 (0.9, 2.0) | <.001 | 1.8 (1.2, 2.5) | <.001 | 1.8 (1.0, 3.2) | .03 | 1.2 (0.7, 2.0) | .02 | 1.4 (0.9, 2.1) | .003 |
| Moderate | 1.9 (1.5, 2.5) | 1.4 (0.9, 2.2) | 2.4 (1.6, 3.7) | 1.7 (0.9, 3.3) | 2.4 (1.2, 4.5) | 2.0 (1.2, 3.3) | |||||||
| Severe | 3.3 (2.3. 4.8) | 3.5 (2.1, 5.8) | 3.3 (1.6, 6.9) | 2.2 (1.0, 4.6) | |||||||||
| Social‡ | Mild | 1.4 (1.1, 1.8) | <.001 | 1.3 (0.9, 2.0) | .001 | 1.6 (1.1, 2.3) | <.001 | 1.7 (0.9, 2.0) | .11 | 1.1 (0.6, 2.0) | .03 | 1.3 (0.8, 2.0) | .004 |
| Moderate | 1.8 (1.4, 2.3) | 1.3 (0.8, 2.0) | 2.1 (1.4, 3.3) | 1.6 (0.9, 3.2) | 2.3 (1.2, 4.3) | 2.0 (1.2, 3.4) | |||||||
| Severe | 3.0 (2.0, 4.3) | 3.0 (1.8, 5.1) | 3.0 (1.4, 6.1) | 2.2 (1.0, 4.7) | |||||||||
| Behavioural§ | Mild | 1.4 (1.1, 1.7) | <.001 | 1.3 (0.9, 1.9) | .001 | 1.6 (1.1, 2.4) | <.001 | 1.8 (0.9, 3.3) | .08 | 1.2 (0.7, 2.1) | .03 | 1.3 (0.8, 2.0) | .006 |
| Moderate | 1.7 (1.3, 2.2) | 1.2 (0.8, 1.9) | 2.1 (1.3, 3.2) | 2.0 (1.0, 3.8) | 2.4 (1.2, 4.6) | 2.0 (1.2, 3.4) | |||||||
| Severe | 2.8 (1.9, 4.0) | 2.7 (1.6, 4.6) | 3.2 (1.5, 6.8) | 2.2 (1.0, 4.8) | |||||||||
Abbreviations: HR = hazard ratio; CI = confidence interval; HPV = Human Papillomavirus
*
Adjusted for age and gender
†
Adjusted for age, gender, cancer site (“All sites” only), TNM stage and treatment modality
‡
Adjusted for age, gender, cancer site (“All sites” only), TNM stage, treatment modality, marital status, education and annual household income
§
Adjusted for age, gender, cancer site (“All sites” only), TNM stage, treatment modality, marital status, education, household income per annum, smoking and alcohol intake