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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Nat Med. 2019 Oct 7;25(10):1549–1559. doi: 10.1038/s41591-019-0592-2

Extended Data Fig. 10. Dynamic occurrence of expanded intratumoral ubiquitous TCRs in blood.

Extended Data Fig. 10

a, The proportion of expanded intratumoral ubiquitous (red circles) and regional (gray circles) TCRs (β-chain) detected within the blood for all patients (the Mann–Whitney P value is shown; n = 45). b, The frequency (number of TCR sequences detected, as a proportion of the total number of TCRs) of expanded intratumoral ubiquitous (red circles) and regional (gray circles) TCRs (β-chain) in the peripheral blood at the time of primary NSCLC surgery (the Mann–Whitney P value is shown; n = 42 for ubiquitous, n = 22 for regional). c, The proportion of expanded intratumoral ubiquitous (left), expanded intratumoral regional (middle) and expanded nontumor lung (right) TCRs (β-chain) that were detected in the blood at the time of primary NSCLC surgery and at routine follow-up (the median time to follow-up was just under 2 years) (the Mann–Whitney P value is shown; n = 14 for ubiquitous, regional and nontumor lung). d, The proportion of expanded intratumoral ubiquitous (left) and regional (right) α-chain (top) and β-chain (bottom) sequences that were detected in the blood at the time of primary NSCLC surgery and at disease recurrence (the median time to first recurrence was 350 d) (the Mann–Whitney P value is shown; n = 14 for α-chains and n = 15 for β-chains).