Skip to main content
. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Nat Med. 2019 Oct 7;25(10):1549–1559. doi: 10.1038/s41591-019-0592-2

Extended Data Fig. 2. Tumor and nontumor regions contain a highly diverse polyclonal TCR repertoire.

Extended Data Fig. 2

a–c, Graphs depicting the total number of TCR α-chain and β-chain segments sequenced (left), the number of unique TCR sequences detected (middle) and the correlation between the total number of TCR α-chain and β-chain segments sequenced (right) in multiregion tumors (n = 220) (a), nontumor lung (n = 64) (b) and PBMCs (n = 56) (c). Spearman’s rank correlation P values are shown. d, The relationship between the total number of TCRs in each region (expressed as log2) and the transcriptional score for a set of genes specifically expressed in T cells (see Methods). The Spearman’s rank correlation coefficient and P value are shown; n = 99.