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. Author manuscript; available in PMC: 2019 Dec 3.
Published in final edited form as: Science. 2019 May 17;364(6441):689–692. doi: 10.1126/science.aav9406

Fig. 3. The high-affinity inhibitor zosuquidar stabilizes a distinct IF conformation of Pgp.

Fig. 3.

(A) Ribbon representation of zosuquidar-bound Pgp cryo-EM structure (PDB code 6FN1) highlighting the positions of spin-label pairs as purple spheres. (B) Distance distributions obtained in nanodiscs for apo-Pgp, zosuquidar-bound nucleotide-free Pgp, and the HES (ADP-Vi). Predicted distributions are shown as dotted lines. Arrows highlight components on the intracellular side of the TMD and at the A-loops that are either not observed or are minor components in apo-Pgp. The y axes in Figs. 1 and 3 are identical.