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Inactivation of chemokine-mediated lymphocyte infiltration by proteolytic cleavage. A Secretion of the chemokines CXCL9, CXCL10, and CXCL11 as well as shedding of CX3CL1/fractalkine leads to chemotactic recruitment of tumor-suppressive lymphocytes to the tumor site. B Chemokine-targeted cleavage by proteases, such as MMPs, cathepsins, and DPPs, impairs lymphocytic infiltration, leading to reduced amounts of immune cells in the tumor microenvironment
