Table 3.
Ectopic fat accumulation
| Variable | Liraglutide (n = 23) | Placebo (n = 26) | Mean (95% CI) change from baseline (liraglutide vs placebo) | p value | ||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 26 weeks | Change from baseline | Baseline | 26 weeks | Change from baseline | |||
| VAT, cm2 | 207 ± 87 | 203 ± 88 | −8 ± 33 | 204 ± 63 | 200 ± 55 | 0 ± 27 | −7 (−24, 10) | 0.41 |
| SAT, cm2 | 361 ± 142 | 339 ± 131 | −28 ± 40 | 329 ± 107 | 333 ± 125 | 3 ± 30 | −29 (−51, −8) | 0.007 |
| HTGC, % | 18.1 ± 11.2 | 12.0 ± 7.7 | −6.3 ± 7.1 | 18.4 ± 9.4 | 14.7 ± 10.0 | −4.0 ± 4.6 | −2.1 (−5.3, 1.0) | 0.17 |
| MTGC, % | 1.5 ± 0.6 | 1.2 ± 0.6 | −0.3 ± 0.5 | 1.3 ± 0.5 | 1.2 ± 0.6 | −0.0 ± 0.5 | −0.1 (−0.4, 0.2) | 0.39 |
| Epicardial fat, cm2 | 8.9 ± 4.3 | 9.1 ± 4.7 | 0.3 ± 3.0 | 9.6 ± 4.1 | 9.6 ± 4.6 | 0.0 ± 2.2 | 0.2 (−1.5, 1.8) | 0.85 |
| Paracardial fat, cm2 | 25.7 ± 10.9 | 24.7 ± 10.9 | −1.1 ± 6.0 | 20.6 ± 10.0 | 22.0 ± 10.3 | 1.4 ± 5.7 | −1.8 (−5.2, 1.6) | 0.28 |
| Pericardial fat, cm2 | 34.6 ± 13.4 | 33.8 ± 13.9 | −0.8 ± 7.4 | 30.2 ± 12.3 | 31.7 ± 12.4 | 1.5 ± 5.7 | −1.8 (−5.9, 2.3) | 0.39 |
Data are presented as mean ± SD