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. 2019 Nov 27;10:2758. doi: 10.3389/fimmu.2019.02758

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Copyright © 2019 Schoon, Ort, Huesker, Geissler and Rakow.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequential anteroposterior radiographs of the patient's right knee indicate progression of bone loss and photographs of the right leg show persisting eczema. (A) Radiography prior to primary knee replacement depicts joint degeneration secondary to rheumatoid arthritis, 2009/03. (B) Pre-revisional radiograph indicates peri-implant bone loss and loosening of the tibial component, 2012/03. (C) Post-revisional radiograph depicts intense intraoperative usage of cement and progressive bone loss, 2012/07. (D) Radiographic status at the time of hypersensitivity diagnostics, 03/2018. (E) Latest radiographic status (patient in supine position), 01/2019. (F) Eczema at the time of hypersensitivity diagnostics, 03/2018. (G) Follow-up examination in the aftermath of rituximab therapy indicated an unimproved cutaneous status, 03/2019.