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. 2019 Nov 27;10:2812. doi: 10.3389/fimmu.2019.02812

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Copyright © 2019 Polito, Nigro, Pecoraro, Monaco, Perna, Sanduzzi, Genovese, Spadaro and Daniele.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AdipoR1 and AdipoR2 expression was higher in lymphocyte subpopulations of treatment-naïve CVID patients than in those of healthy controls. Their expression decreases 24 h post the first Ig replacement therapy. (A–C) Percentage of AdipoR1- AdipoR2- and T-cadherin-positive cells on the lymphocyte subpopulations (CD19+ B cells, CD19+CD27+ B-activated cells, CD3–CD56+ NK lymphocytes and CD14+ monocytes) from healthy controls and treatment-naïve CVID patients before and 24 h after the first Ig infusion. Data obtained from two independent experiments performed by flow-cytometry in triplicate. *p ≤ 0.05.