Table 1.
Contractile parameters in EHTs under spontaneous contraction.
| WT | KI-NT | KI-S282 | KI-D282 | |
|---|---|---|---|---|
| Number of values | 51 | 61 | 26 | 20 |
| Force (µN) | 35.73 ± 2.32 | 42.52 ± 2.06 | 42.04 ± 4.10 | 43.4 ± 5.28 |
| Rate (bpm) | 174 ± 6 | 207 ± 7** | 173 ± 8 | 167 ± 13 |
| Contraction velocity (µN/ms) | 0.89 ± 0.06 | 1.06 ± 0.06 | 0.99 ± 0.10 | 1.01 ± 0.12 |
| T120% (ms) | 63.41 ± 2.86 | 52.84 ± 1.99** | 55.46 ± 1.94 | 65.80 ± 5.57 |
| Relaxation velocity (µN/ms) | 0.70 ± 0.05 | 0.83 ± 0.05 | 0.78 ± 0.07 | 0.82 ± 0.1 |
| T220% (ms) | 104.70 ± 5.38 | 87.98 ± 3.63* | 91.00 ± 7.23 | 99.50 ± 11.19 |
Data are expressed as mean ± SEM. Groups were compared with the one-way ANOVA, followed by Dunnet’s multiple comparison test vs WT. *P < 0.05 and ** P < 0.01 vs WT EHTs.