Table 1.

Review of cases of dupilumab-associated conjunctivitis

Study	Pts (N)	Exposure	Baseline	Conjunctivitis characteristics	Conjunctivitis onset	DUP discontinuation
Wollenberg et al. [22]	13	DUP dosage NR	8/13 (61.5%) had IGA score 4; 5/13 had IGA score 3; four pts had history of conjunctivitis	Bilateral hyperemia (particularly of limbus). Limbal edema. Pruritus, irritation, tearing, decreased visual acuity. Dx by dermatologist	After mean 16.8 wk of treatment (range 2.9–55.6)	No
Treister et al. [11]	12	DUP 600 mg loading dose and 300 mg every 2 wk thereafter	9/12 (75%) had IGA score 4; 3/12 had IGA score 3; all had childhood history of AD; none had history of eye conditions	Hyperemia, pruritus, irritation, discharge, dryness, decreased visual acuity. Dx by ophthalmologist	After mean 15.8 wk of treatment (range 8–41)	Yes (2/12)
Maudinet et al. [23]	10	DUP dosage NR	Baseline mean SCORAD 60.4 ± 20 and mean EASI 37 ± 17; 4/10 had history of allergic conjunctivitis	Hyperemia, dryness, follicular conjunctivitis without keratitis. Dx by ophthalmologists	After mean 3.75 mo of treatment (range 1.8–6)	Yes (1/10)
Ivert et al. [24]	7	DUP 600 mg loading dose and 300 mg biweekly thereafter	Baseline EASI of those who developed conjunctivitis: 30.6. All pts also had history of asthma or allergic rhinoconjunctivitis	Ocular surface findings NR. Dx by ophthalmologists	NR	Yes (1/7)
Shen et al. [25]	2	300 mg every 2 wk	Both had history of AD. No known history of eye conditions	Bilateral hyperemia (particularly of limbus), nodular swelling, subconjunctival hemorrhages, follicular reaction. Dx by ophthalmologists	After 3 wk (pt A); after 1 mo (pt B)	No
Barnes et al. [26]	1	Weekly DUP as per a phase III trial (specific trial/dosages NR)	History of AD. No known history of eye conditions	Bilateral hyperemia (particularly of limbus), cicatricial ectropion with punctual stenosis of lower eyelids. Dx by ophthalmologist	After 2 mo	Yes
Levine et al. [27]	1	300 mg every 2 wk	History of AD (80% body involvement). No known history of eye conditions	Bilateral hyperemia, cicatrizing blepharoconjunctivitis, punctual stenosis. Dx by ophthalmologist	After 14 wk	Decreased frequency to every 4 wk
Fukuda et al. [30]	1	DUP dosage NR	History of AD since age 5 years; no known history of eye conditions	Bilateral hyperemia, pruritus, papillae and follicular reaction in tarsal conjunctiva, proliferative lesion. Dx by ophthalmologist	Bilateral pruritus and discharge several days after; hyperemia and proliferative lesion 3 mo after	No
Zirwas et al. [33]	1	DUP 600 mg loading dose and 300 mg every 2 wk thereafter	Lifelong history of severe AD; history of dry eyes	Bilateral hyperemia, swelling and thickening of upper and lower eyelids. Dx by ophthalmologist	Conjunctivitis and blepharitis developed after 3 mo	No

AD atopic dermatitis, DUP dupilumab, Dx diagnosed, EASI Eczema Area and Severity Index, IGA Investigator Global Assessment, mo month(s), NR not reported, pt(s) patient(s), SCORAD SCORing Atopic Dermatitis, wk week(s)