Table 1.
Radiosensitizing effect of ARID1B knockdown for ARID1A-deficient and - proficient cell lines from the clonogenic assay.
| Cell line | Dose modifying factor (αARID1B − αctr) [Gy−1] |
p |
|---|---|---|
| (a) | ||
| SW48 (mt) | −0.259 ± 0.020 | <0.0001 |
| RKO (mt) | −0.151 ± 0.013 | <0.0001 |
| LS180 (mt) | −0.136 ± 0.024 | <0.0001 |
| HCT116 (wt) | −0.070 ± 0.021 | 0.0012 |
| Colo320DM (wt) | −0.045 ± 0.026 | 0.092 |
| HCT15 (wt) | −0.020 ± 0.019 | 0.27 |
| PCS201-010 | +0.090 ± 0.022 | 0.0001 |
| PCS201-012 | −0.120 ± 0.063 | 0.06 |
| (b) Surviving fraction at 4 Gy of ARID1B-defiicent and - proficient cell lines from the clonogenic assay | ||
| Cell line | Surviving fraction at 4 Gy | |
| SW48 (mt) | 1.92% (95% CI: 1.49–2.48%) | |
| RKO (mt) | 5.84% (95% CI: 5.15–6.62%) | |
| LS180 (mt) | 4.27% (95% CI: 3.72–4.92%) | |
| HCT116 (wt) | 4.43% (95% CI: 3.83–5.12%) | |
| Colo320DM (wt) | 5.28% (95% CI: 4.39–6.35%) | |
| HCT15 (wt) | 14.2% (95% CI: 13.2–15.4%) | |
| PCS201-10 | 4.55% (95% CI: 4.15–5.00%) | |
| PCS201-012 | 1.96% (95% CI: 1.38–4.08%) | |