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. 2019 Dec 3;9:18211. doi: 10.1038/s41598-019-54456-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Venn diagram illustrating the number of genes that are significantly differentially expressed in the HPC of young female F₁-F₃ offspring following prenatal synthetic glucocorticoid treatment of the F₀ pregnancy and the number of genes that overlap between generations (Veh F₁ (n = 6), F₂ (6), F₃ (6); sGC F₁ (5), F₂ (6), F₃ (7)). (B) Heatmap of the 18 genes that are differentially expressed in F₁ and F₃ female offspring. Values indicate the log-fold change in gene expression in sGC animals relative to control, color further indicates the direction of change (green: significantly down-regulated; red: significantly up-regulated; grey: not significant).