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. 2019 Dec 3;9:18211. doi: 10.1038/s41598-019-54456-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Visualization of significant differences in expression and DNA methylation, overlaid with genomic loci in (A) F₁ and (B) F₃. Top row represents significant changes in gene expression associated with prenatal sGC. Red indicates significantly increased expression (FDR < 0.05), green indicates significantly decreased expression (FDR < 0.05). Second row represents significant changes in methylation. Blue indicates significantly decreased methylation (>10%, FDR < 0.05), red indicates significantly increased methylation (>10%, FDR < 0.05). Enhancer row identifies which regions of the genome were captured as enhancers. Gene tracks are represented above the gene names in blue, with horizontal lines representing intron sequences and coding exons represented by blocks.