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. 2019 Dec 3;9:18211. doi: 10.1038/s41598-019-54456-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CpG distributions with respect to transcription start sites (TSS) in (A) F₁ distribution of all CpG sites captured with respect to distance to TSS. (B) Distribution of significantly differentially methylated CpGs in F₁ (p < 0.05, FDR < 0.05) with respect to distance to TSS. (C) F₂ distribution of all CpG sites captured with respect to distance to TSS. (D) Distribution of significantly differentially methylated CpGs in F₂ (p < 0.05, FDR < 0.05) with respect to distance to TSS. (E) F₃ distribution of all CpG sites captured with respect to distance to TSS. (F) Distribution of significantly differentially methylated CpGs in F₃ (p < 0.05, FDR < 0.05) with respect to distance to TSS. Red indicates increased methylation, while blue indicates decreased methylation. Veh F₁ (n = 6), F₂ (6), F₃ (7); sGC F₁ (6), F₂ (6), F₃ (5).