Table 1.

Gene sets that are enriched in F1, F2, and F3 female hippocampus after antenatal sGC exposure.

Name	Type	Generation	Effect of sGC	SIZE	NES	NOM p-val	FDR q-val
GO_COLLAGEN_FIBRIL_ORGANIZATION	c5	F1	Negative	31	1.64	0.009	0.174
GO_COLLAGEN_FIBRIL_ORGANIZATION	c5	F2	Negative	31	1.92	<0.001	0.060
GO_COLLAGEN_FIBRIL_ORGANIZATION	c5	F3	Positive	31	−1.89	<0.001	0.056
GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS	c5	F1	Positive	18	−1.98	0.005	0.084
GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS	c5	F2	Positive	17	−1.79	0.008	0.102
GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS	c5	F3	Positive	17	−1.76	0.005	0.100
GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT	c5	F1	Negative	56	1.90	<0.001	0.015
GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT	c5	F2	Negative	56	2.02	<0.001	0.012
GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT	c5	F3	Positive	46	−1.77	0.005	0.165
GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS	c5	F1	Negative	49	1.83	<0.001	0.057
GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS	c5	F2	Negative	50	1.98	<0.001	0.044
GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS	c5	F3	Positive	49	−2.16	<0.001	0.006
GO_NEUROPEPTIDE_SIGNALING_PATHWAY	c5	F1	Negative	51	1.74	0.001	0.116
GO_NEUROPEPTIDE_SIGNALING_PATHWAY	c5	F2	Positive	55	−1.70	0.006	0.150
GO_NEUROPEPTIDE_SIGNALING_PATHWAY	c5	F3	Negative	54	2.20	<0.001	0.001
REACTOME_COLLAGEN_FORMATION	c2	F1	Negative	48	1.96	<0.001	0.003
REACTOME_COLLAGEN_FORMATION	c2	F2	Negative	49	2.47	<0.001	<0.001
REACTOME_COLLAGEN_FORMATION	c2	F3	Positive	48	−2.15	<0.001	<0.001
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	c2	F1	Negative	58	1.98	<0.001	0.002
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	c2	F2	Negative	59	2.36	<0.001	<0.001
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	c2	F3	Positive	58	−2.26	<0.001	<0.001
GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS	c5	F1	Negative	58	1.83	0.001	0.054
GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS	c5	F2	Negative	60	1.77	<0.001	0.210
GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS	c5	F3	Positive	58	−1.86	0.002	0.072

Type: collections of gene sets; c5 = gene ontology, c2 = curated gene sets from published data sets. Effect of sGC: describes relationship between treatment with sGC and the expression of genes within a gene set, positive-increased expression, negative-decreased expression. Size: number of genes in the gene set. NES: normalized enrichment score used to compare gene sets of different sizes. FDR: false discovery rate, the probability that a gene set with a specific NES is a false positive. (Veh F₁ (n = 6), F₂ (6), F₃ (6); sGC F₁ (5), F₂ (6), F₃ (7)).