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. 2019 Dec 3;9:18202. doi: 10.1038/s41598-019-54804-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Simulated median afatinib plasma concentration-time profiles after oral administration of 40 mg/day afatinib for different scenarios regarding the median and 95% prediction interval of the 1000 simulated profiles for a typical reference patient (age 66.7 years; BMI 21.8 kg/m²; AST 25.3 IU/L; Ccr 79.9 mL/min). The solid lines show the median values, and the shaded area is the 95% prediction interval.