Table 1.
Demographic and clinicopathologic characteristics of patients.
| Characteristics | n | |
|---|---|---|
| Sex | 34 | |
| Male | 11 | |
| Female | 23 | |
| Tumor histology | ||
| Adenocarcinoma | 34 | |
| ECOG score | ||
| 0–1 | 28 | |
| 2 | 5 | |
| 3 | 1 | |
| EGFR mutation status | ||
| Ex19 del. | 18 | |
| Ex19 del.+ T790M | 1 | |
| Ex19 del. + Ex19 A755G | 1 | |
| L858R | 9 | |
| L858R+ Ex18 G719C | 1 | |
| Ex18 G719S | 1 | |
| Ex18 G719C | 1 | |
| Ex20 ins | 1 | |
| S768I | 1 | |
| Prior CTX | 24 | |
| Prior EGFR TKI | 21 | |
| Value (units) | Mean ± SD | Range |
| Age (years) | 66.8 ± 1.5 | 45–86 |
| Height (cm) | 156.5 ± 1.7 | 138.0–186.0 |
| Weight (kg) | 53.8 ± 1.6 | 35.5–79.1 |
| BMI (kg/m2) | 21.9 ± 0.5 | 15.2–28.1 |
| AST (IU/L) | 25.6 ± 2.0 | 13–65 |
| ALT (IU/L) | 19.7 ± 2.6 | 5–77 |
| Cre (mg/dL) | 0.64 ± 0.03 | 0.39–1.13 |
| Ccr (mL/min) | 80.8 ± 3.8 | 42.3–131.8 |
Each value represents mean ± SD with the range in parentheses, unless specified otherwise. Ccr value was calculated using the Cockroft-Gault method.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; Ccr, creatinine clearance; Cre, serum creatinine; CTX, chemotherapy; ECOG, Eastern Cooperative Oncology Group; EGFR, epidermal growth factor; TKI, tyrosine kinase inhibitor; SD, standard deviation.