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. 2019 Nov 26;9:1294. doi: 10.3389/fonc.2019.01294

Figure 2.

Figure 2

p38α is activated in cancer cells in PDAC patient samples. (A) Micrographs of H&E and immunohistochemistry staining with CD163, PDGFRβ, and αSMA. Quantification of CD163+, PDGFRβ+, and αSMA+ signals (n = 8 random fields per group). (B) Micrographs of immunohistochemistry staining with p38 and Phospho-p38 in PDAC and adjacent pancreas samples. Quantification of p38+, Phospho-p38+ signals (n = 8 random fields per group). (C) Pathological analysis of p38 and Phospho-p38 in PDAC and adjacent pancreas samples (n = 20 samples per group). (D) Protein expression levels of p38 and Phospho-p38 in human PDAC tissues and adjacent pancreas (n = 20 samples per group). (E) protein expression levels of p38 and Phospho-p38 in various human cell lines (n = 3 samples per group). (F) Cell viabilities of Pan02 cell lines treated with 3.125–200 μM SB203580 for 24 h (n = 6 samples per group). *p < 0.05; **p < 0.01; ***p < 0.001. NS = not significant. Data presented as mean ± s.e.m.