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. 2019 Nov 27;10:2745. doi: 10.3389/fimmu.2019.02745

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Copyright © 2019 Roy, Kumar, Bossier, Norouzitallab and Vanrompay.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap showing transcription levels for innate immune-related genes analyzed in three subsequent brine shrimp generations F1, F2, and F3 originating from phloroglucinol-treated parents. Results for non-infected larvae and juveniles and for larvae infected with V. parahaemolyticus or V. harveyi are presented. Gene upregulation in TF1 to TF3 as compared to CF1 to CF3 is visualized in red and gene downregulation upregulation in TF1 to TF3 as compared to CF1 to CF3 in green. An asterisk * represents a significant difference between the treatment and control groups at each respective generation (*P < 0.05, **P < 0.01, ***P < 0.001).