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. 2019 Nov 27;10:1229. doi: 10.3389/fgene.2019.01229

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Copyright © 2019 Declerck and Vanden Berghe

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Weighted Correlation Network Analysis co-methylation consensus module in whole blood of other inflammaging diseases. (A) Correlation heatmap representing the Pearson’s correlation coefficients between the gene significance values (t-statistics) of the consensus module ME21 CpG sites across six chronic inflammaging diseases: atherosclerosis (athero), Alzheimer’s disease, Parkinson’s disease, obesity (obese), osteoporosis (osteo), schizophrenia (schizo), and multiple sclerosis (see Table 2). Red means a positive correlation and blue a negative correlation. (B) Estimated blood immune cell type composition shifts in the different chronic inflammaging diseases compared to healthy controls. Error bars represent 95% confidence intervals.