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. 2019 Nov 27;9:1324. doi: 10.3389/fonc.2019.01324

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Copyright © 2019 Chae, Niesel, Schulz, Klemm, Joyce, Prümmer, Brill, Bergs, Rödel, Pilatus and Sevenich.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic changes in response to tumor progression and radiotherapy (A) Signal intensity of tCho, tCr, and tNAA (upper panel) and ratio of tCho/tCr, tCho/tNAA, and tNAA/tCr (lower panel) in tumor-bearing untreated mice (n = 4) and tumor-bearing mice with WBRT (n = 3) at short echo time (16.5 ms) (depicted as arbitrary units). (B) Signal intensity of tCho, tCr, tNAA and Lac (upper panel) and ratio of tCho/tCr, tCho/tNAA, tNAA/tCr, and Lac/tCr (lower panel) in tumor-bearing untreated mice (n = 3) and tumor-bearing mice with WBRT (n = 3) at long echo time (135 ms) (depicted as arbitrary units). P-values were calculated based on linear regression analysis and comparison between the slopes. n.s. = not significant, *P < 0.05, **P < 0.01, ***P < 0.001.