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. 2014 Sep 9;1:11. doi: 10.1186/2197-7364-1-11

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© Conti; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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A prostate cancer patient with¹¹ C-choline injection. (a) The original fused PET/CT image, with no simulated lesion (the ‘true’ original large tumor is visible in the prostate); (b) the OSEM reconstruction with the same parameters as in the original image (5.5 × 5.5 × 3.3 mm³ voxels, OSEM with 20 subsets, 2 iterations, and a 6-mm post-reconstruction filter), after insertion of two 6 mm lesions with SUV = 8; (c) the PSF + TOF reconstruction with 2-mm voxel size and 4-mm filter, after insertion of the two 6-mm lesions. The arrows point to the location of the simulated lesions.