Table 3.

KEGG Pathway Analysis Based On LWDH Pill–Type 2 Diabetes Mellitus Network

No.	Pathway ID	Pathway Name	P value	Count	Gene Name
1	05167	Kaposi sarcoma-associated herpesvirus infection	4.39E-20	31	PTGS2, IL6, RELA, AKT1, VEGFA, CCND1, FOS, CDKN1A, BAX, CASP9, MAPK1, RB1, JUN, CASP3, NFKBIA, CASP8, RAF1, HIF1A, STAT1, MYC, ICAM1, CXCL8, CXCL2, CHUK, E2F1, E2F2, IKBKB, MAPK8, PPP3CA, GSK3B, MTOR
2	05163	Human cytomegalovirus infection	1.35E-17	31	PTGS2, IL6, RELA, EGFR, AKT1, VEGFA, CCND1, CDKN1A, BAX, CASP9, MAPK1, RB1, CASP3, ELK1, NFKBIA, CASP8, RAF1, PRKCA, MYC, IL1B, CCL2, PTGER3, CXCL8, PRKCB, CHUK, E2F1, E2F2, IKBKB, PPP3CA, GSK3B, MTOR
3	05418	Fluid shear stress and atherosclerosis	1.11E-21	29	RELA, AKT1, VEGFA, BCL2, FOS, MMP2, MMP9, JUN, HMOX1, CAV1, ICAM1, IL1B, CCL2, SELE, VCAM1, NOS3, PLAT, THBD, IFNG, IL1A, NCF1, GSTP1, NFE2L2, NQO1, CHUK, GSTM1, GSTM2, IKBKB, MAPK8
4	05161	Hepatitis B	1.23E-19	29	IL6, RELA, AKT1, BCL2, FOS, CDKN1A, BAX, CASP9, MMP9, MAPK1, RB1, JUN, CASP3, ELK1, NFKBIA, CASP8, RAF1, PRKCA, STAT1, MYC, CXCL8, PRKCB, BIRC5, CHUK, E2F1, E2F2, IKBKB, MAPK8, CCNA2
5	04933	AGE-RAGE signaling pathway in diabetic complications	8.84E-25	28	IL6, RELA, AKT1, VEGFA, CCND1, BCL2, BAX, MMP2, MAPK1, JUN, CASP3, PRKCA, STAT1, F3, ICAM1, IL1B, CCL2, SELE, VCAM1, CXCL8, PRKCB, NOS3, THBD, SERPINE1, COL1A1, IL1A, COL3A1, MAPK8
6	05160	Hepatitis C	5.23E-17	26	RXRA, RELA, EGFR, AKT1, CCND1, CDKN1A, BAX, CASP9, MAPK1, EGF, RB1, CASP3, NFKBIA, CASP8, RAF1, STAT1, MYC, IFNG, CLDN4, PPARA, CXCL10, CHUK, E2F1, E2F2, IKBKB, GSK3B
7	05215	Prostate cancer	3.33E-21	25	AR, MMP3, RELA, EGFR, AKT1, CCND1, BCL2, CDKN1A, CASP9, PLAU, MMP9, MAPK1, EGF, RB1, NFKBIA, RAF1, ERBB2, PLAT, GSTP1, CHUK, E2F1, E2F2, IKBKB, GSK3B, MTOR
8	05225	Hepatocellular carcinoma	3.91E-14	24	EGFR, AKT1, CCND1, BCL2L1, CDKN1A, BAX, MAPK1, RB1, ELK1, RAF1, PRKCA, HMOX1, MYC, PRKCB, GSTP1, NFE2L2, NQO1, E2F1, E2F2, IGF2, GSTM1, GSTM2, GSK3B, MTOR
9	04668	TNF signaling pathway	2.32E-17	23	PTGS2, IL6, MMP3, RELA, AKT1, FOS, MMP9, MAPK1, JUN, CASP3, NFKBIA, CASP8, ICAM1, IL1B, CCL2, SELE, VCAM1, CXCL2, CXCL10, CHUK, IRF1, IKBKB, MAPK8
10	04657	IL-17 signaling pathway	7.05E-18	22	PTGS2, IL6, MMP3, RELA, FOS, MMP9, MAPK1, JUN, CASP3, NFKBIA, CASP8, MMP1, IL1B, CCL2, CXCL8, IFNG, CXCL2, CXCL10, CHUK, IKBKB, MAPK8, GSK3B
11	05164	Influenza A	4.33E-12	22	IL6, PRSS1, RELA, AKT1, CASP9, MAPK1, JUN, NFKBIA, RAF1, PRKCA, STAT1, ICAM1, IL1B, CCL2, CXCL8, PRKCB, IFNG, IL1A, CXCL10, IKBKB, MAPK8, GSK3B
12	05212	Pancreatic cancer	9.09E-19	21	RELA, EGFR, AKT1, VEGFA, CCND1, BCL2L1, CDKN1A, BAX, CASP9, MAPK1, EGF, RB1, RAF1, STAT1, ERBB2, CHUK, E2F1, E2F2, IKBKB, MAPK8, MTOR
13	04066	HIF-1 signaling pathway	5.70E-16	21	IL6, RELA, EGFR, AKT1, VEGFA, BCL2, CDKN1A, MAPK1, EGF, PRKCA, HIF1A, ERBB2, HMOX1, PRKCB, NOS3, SERPINE1, IFNG, INSR, HK2, NOS2, MTOR
14	05224	Breast cancer	1.75E-12	21	PGR, ESR1, EGFR, AKT1, CCND1, FOS, CDKN1A, BAX, MAPK1, EGF, RB1, JUN, RAF1, ERBB2, MYC, E2F1, E2F2, GSK3B, NCOA1, ESR2, MTOR
15	01522	Endocrine resistance	5.32E-15	20	ESR1, EGFR, AKT1, CCND1, BCL2, FOS, CDKN1A, BAX, MMP2, MMP9, MAPK1, RB1, JUN, RAF1, ERBB2, E2F1, E2F2, MAPK8, ESR2, MTOR
16	05222	Small cell lung cancer	2.61E-14	19	PTGS2, RXRA, RELA, AKT1, CCND1, BCL2, BCL2L1, CDKN1A, BAX, CASP9, RB1, CASP3, NFKBIA, MYC, CHUK, E2F1, E2F2, NOS2, IKBKB
17	05142	Chagas disease (American trypanosomiasis)	1.87E-13	19	IL6, RELA, AKT1, FOS, MAPK1, IL10, JUN, NFKBIA, CASP8, IL1B, CCL2, CXCL8, IL2, SERPINE1, IFNG, CHUK, NOS2, IKBKB, MAPK8
18	04620	Toll-like receptor signaling pathway	2.25E-13	19	IL6, CD14, LBP, RELA, AKT1, FOS, MAPK1, JUN, NFKBIA, CASP8, STAT1, IL1B, CXCL8, CXCL11, CXCL10, CHUK, SPP1, IKBKB, MAPK8
19	05210	Colorectal cancer	8.32E-14	18	EGFR, AKT1, CCND1, BCL2, FOS, CDKN1A, BAX, CASP9, MAPK1, EGF, JUN, CASP3, RAF1, MYC, BIRC5, MAPK8, GSK3B, MTOR
20	04064	NF-kappa B signaling pathway	5.17E-13	18	PTGS2, CD14, LBP, RELA, BCL2, BCL2L1, PLAU, NFKBIA, ICAM1, IL1B, VCAM1, CXCL8, PRKCB, PARP1, CXCL2, CHUK, CD40LG, IKBKB