Table 1.

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Cell Death in Myocardial Infarction and Heart Failure
1. Cell death can occur in a passive manner or through multiple actively mediated cell suicide programs referred to collectively as regulated cell death.
2. Regulated heart muscle cell death plays important roles in the pathogenesis of reperfused myocardial infarction (ischemia/reperfusion) and heart failure with reduced ejection fraction.
3. Because regulated cell death is actively mediated through molecular pathways, the possibility exists to inhibit this signaling to reduce cardiac damage and dysfunction from these major cardiac syndromes.