Table 2.
Genetic manipulations of death receptor pathway proteins in mice
| Genotype | Phenotype | Reference Nos. |
|---|---|---|
| Ripk3 –/– | Normal development | 354 |
| Mlkl –/– | Normal development | 530 |
| Ripk1 D138N/D138N | Normal development | 382 |
| Ripk1 K45A/K45A | Normal development | 219, 444 |
| Ripk1 ΔG26F27/ΔG26F27 | Normal development | 288 |
| Procaspase-8 –/– | Lethal E (embryonic day) 10.5 | 495 |
| Procaspase-8 –/–; Ripk3 –/– | Normal development | 221, 361 |
| Procaspase-8 –/–; Mlkl –/– | Normal development | 8 |
| Fadd –/– | Lethal E11.5 | 548 |
| Fadd –/–; Ripk3 –/– | Normal development | 8, 92 |
| Fadd –/–; Mlkl –/– | Normal development | 8, 508 |
| Fadd –/–; Ripk1 –/– | Lethal P (postnatal day) 1–3 | 559 |
| Flip –/– | Lethal E10.5 | 547 |
| Flip –/–; Ripk3 –/– | Lethal E12 | 92 |
| Flip –/–; Ripk3 –/–; Fadd –/– | Normal development | 92 |
| Flip –/–; Ripk3 –/–; Procaspase-8 –/– | Normal development | 221 |
| Flip –/–; Mlkl –/–; Fadd –/– | Normal development | 8 |
| Ripk1 –/– | Lethal P1–3 | 233 |
| Ripk1 –/–; Procaspase-8 –/– | Lethal P1–3 | 93, 402 |
| Ripk1 –/–; Ripk3 –/– | Lethal P1–3 | 93 |
| Ripk1 –/–; Mlkl –/– | Lethal P1–3 | 402 |
| Ripk1 –/–; Ripk3 –/–; Fadd –/– | Normal development | 93 |
| Ripk1 –/–; Ripk3 –/–; Procaspase-8 –/– | Normal development | 93, 219, 402 |
| Ripk1 –/–; Mlkl –/–; Fadd –/– | Normal development | 8 |
| Ripk1 –/–; Procaspase-8 –/–; Dai/Zbp1 –/–; Trif –/– | Normal development | 353 |
| Ripk1 –/–; Tnfr1 –/– | Lethal P1–3 | 93, 402 |
| Ripk1 –/–; Tnfr1 –/–; Trif –/– | Lethal P14–21 | 93 |
| Ripk1 –/–; Tnfr1 –/–; Infar –/– | Lethal P14–21 | 93 |
| Ripk1 –/–; Tnfr1 –/–; Ripk3 –/– | Normal development | 93 |
| Ripk1 mRHIM/mRHIM | Lethal P1–3 | 274, 353 |
| Ripk1 mRHIM/mRHIM; Mlkl –/– | Normal development | 274, 353 |
| Ripk1 mRHIM/mRHIM; Ripk3–/– | Normal development | 274, 353 |
| Ripk1 mRHIM/mRHIM; Dai/Zbp1 –/– | Normal development | 274, 353 |
| Ripk1 mRHIM/mRHIM; Trif –/– | Lethal P1–3 | 353 |
| Ripk3 D161N/D161N | Lethal E11.5 | 352 |
| Ripk3 D161N/D161N; Dai/Zbp1 –/– | Lethal E11.5 | 352 |
| Ripk3 D161N/D161N; Cyld –/– | Lethal E11.5 | 352 |
| Ripk3 D161N/D161N; Trif –/– | Lethal E11.5 | 352 |
| Ripk3 D161N/D161N; Mlkl –/– | Lethal E11.5 | 352 |
| Ripk3 D161N/D161N; Tnfr1 –/– | Lethal E11.5 | 352 |
| Ripk3 D161N/D161N; Flip –/– | Lethal E11.5 | 352 |
| Ripk3 D161N/D161N; Ripk1 –/– | Lethal P1–3 | 352 |
| Ripk3 D161N/D161N; Procaspase-8 –/– | Normal development | 352 |
| Ripk3 K51A/K51A | Normal development | 303 |
| Ripk3 K51A/K51A; Procaspase-8 –/– | Normal development | 303 |