TABLE 5.

Summary of previous studies in which the 4 components of the proposed sncRNA classifier for active TB were observed to be differentially expressed during M. tuberculosis infection^a

Component of the 4-sncRNA classifier for TB	Specimen	Type of clinical specimen/cell examined	Test groups	Direction of regulation	Reference
let-7a-5p	Human U937 macrophages	Macrophages recombinantly expressing the M. tuberculosis antigen Hsp16.3	Wild type vs Hsp16.3 recombinant	↓	Meng et al. 2014 (51)
	Peripheral blood	CD4+ T cells	Control vs TB	—	Fu et al. 2014 (52)
			LTBI vs TB	↑
	Peripheral blood	PBMC	Control vs TB	↓	Fu et al. 2019 (53)
miR-196b-5p	Peripheral blood	Serum	Control vs TB	↑	Zhang et al. 2014 (54)
miR-589-5p	Peripheral blood	Serum	Control vs DS-TB	—	Wang et al. 2016 (55)
			Control vs MDR-TB	↑
			DS-TB vs MDR-TB	↑
SNORD104	None (no available studies)

^aSymbols: ↓ = downregulation; ↑ = upregulation; — = no DE. Abbreviations: LTBI = latent tuberculosis infection; TB = tuberculosis; DS-TB = drug-sensitive TB; MDR-TB = multidrug-resistant TB; DE = differential expression.