Figure 11.
Loss of Mfsd2a does not impede phototransduction. A, Representative families of flash responses from a WT (black) and Mfsd2a−/− (red) rod. Flash strengths ranged from 8.8 to 39,000 photons μm−2 by factors of 4. B, Population average single-photon responses from KO (n = 9) and WT (n = 24) of littermates aged 69 and 70 d, respectively. Average maximal response amplitudes for these populations were 13.2 ± 0.7 and 14.2 ± 0.7 pA, respectively (p = 0.4). C, Plot comparing the time that bright flash response remained in saturation as a function of the natural log of the number of photoexcited rhodopsins (R*), showing the similarity of the behavior of bright flash responses.