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. 2019 Nov 1;218(12):4042–4062. doi: 10.1083/jcb.201907006

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© 2019 Watanabe et al.

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Figure 8. — A model of kinetochore localization of CENP-C during interphase and mitosis. CENP-C localizes to interphase centromeres through interaction of the CENP-C middle region with the CENP–HIKM–LN complex. During mitosis, T651 or T734 in gCENP-C or hCENP-C, respectively, is phosphorylated by CDK1 (depicted as “P”), and this phosphorylation facilitates binding of the CENP-C motif to the CENP-A nucleosome (CENP-A nuc.). Kinetochore localization of CENP-C depends on both CENP–HIKM–NL and the CENP-A nucleosome during mitosis.