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. 2019 Nov 5;218(12):3903–3911. doi: 10.1083/jcb.201906148

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© 2019 Peterman and Prekeris

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 2. — Midbody-mediated abscission concludes cell division. In late telophase, the midbody recruits and tethers Rab11 and Rab35 endosomes. Concurrent with this, microtubules are severed in a spastin-dependent manner, and actin is depolymerized via delivery of Rab11 and Rab35 cargo proteins. From here, two models exist. After secondary ingression, either ESCRT-III filaments can be recruited to the future abscission site (left) or ESCRT-III filaments can elongate and constrict from the midbody (right). Ultimately, ESCRT-III filaments facilitate membrane scission and the conclusion of cell division.