Table 2.

Adjusted associations of fluctuations in sleep disturbances and cognitive performance in older breast cancer patients over time and interactions of sleep effects with genotype

Sleep Disturbance Predicting Attention, Processing, Executive Function
	N=319			N=292 +APOE			N=277 +BDNF			N=269 +COMT
Variable	Est	SE	p	Est	SE	p	Est	SE	p	Est	SE	p
Between Person Sleep	0.10	0.09	0.268	0.11	0.11	0.292	0.02	0.12	0.846	0.41	0.22	0.059
Within Person Sleep	−0.07	0.04	0.071	−0.07	0.04	0.087	−0.08	0.05	0.083	−0.13	0.09	0.115
Gene				−0.07	0.09	0.435	−0.05	0.08	0.495	0.14	0.09	0.123
Gene X BP Sleep				−0.02	0.23	0.915	0.21	0.21	0.302	−0.39	0.24	0.105
Gene X WP Sleep				0.07	0.10	0.473	0.09	0.09	0.297	0.09	0.09	0.337
Sleep Disturbance Predicting Learning and Memory
	N=319			N=292 +APOE			N=277 +BDNF			N=269 +COMT
Variable	Est	SE	p	Est	SE	p	Est	SE	p	Est	SE	p
Between Person Sleep	−0.06	0.11	0.614	−0.28	0.13	0.034	−0.22	0.15	0.133	0.21	0.26	0.429
Within Person Sleep	−0.01	0.05	0.846	0.02	0.06	0.685	0.07	0.07	0.256	0.03	0.12	0.829
Gene				−0.14	0.11	0.201	0.03	0.09	0.712	−0.10	0.11	0.356
Gene X BP Sleep				0.91	0.28	0.001a	0.38	0.25	0.135	−0.35	0.30	0.239
Gene X WP Sleep				−0.14	0.15	0.324	−0.11	0.12	0.366	0.01	0.13	0.934
Sleep disturbance predicting self-reported perceived cognitive function
	N=319			N=292 +APOE			N=277 +BDNF			N=269 +COMT
Variable	Est	SE	p	Est	SE	p	Est	SE	p	Est	SE	p
Between Person Sleep	−7.26	2.73	0.008c	−6.89	3.18	0.036	−9.82	3.57	0.006	−10.11	6.47	0.119
Within Person Sleep	−4.43	1.41	0.002b	−4.03	1.59	0.012	−5.21	1.73	0.003	1.26	3.18	0.693
Gene				−0.47	2.64	0.858	−0.69	2.19	0.753	2.59	2.66	0.330
Gene X BP Sleep				1.97	6.88	0.775	6.54	6.23	0.295	4.71	7.24	0.515
Gene X WP Sleep				−3.67	3.87	0.344	0.82	3.31	0.803	−8.20	3.62	0.024d

Note: Models adjusting for age, reading score, race, site, and treatment.

Notes: All models control for age, race, WRAT score, site, chemotherapy/hormone treatment group. Additional models adjusted for frailty, anxiety, depressive symptoms, or sleep medication, with no appreciable modifications to the effect of sleep disturbance.

FDR adjusted

^ap=.0125;

^bp=.017,

^cp=.025,

^dp=.05.