Table 2. All-cause mortality in HIV-positive individuals: hazard ratios and 95 per cent confidence intervals (Weibull regression), Uganda 2000–14.
| Variables1 | Pre-ART (2000–03)2 | ART (2004–14)3 | |
|---|---|---|---|
| Untreated | Treated | ||
| Calendar year (2000–03) | 0.78 | – | – |
| (0.69–0.88) | – | – | |
| Calendar year (2004–08) | – | 0.72 | 0.64 |
| – | (0.67–0.77) | (0.57–0.71) | |
| Calendar year (2009–14) | – | 0.87 | 0.96 |
| – | (0.77–0.99) | (0.79–1.16) | |
| Male4 | 0.65 | 0.93 | 0.93 |
| (0.45–0.94) | (0.76–1.14) | (0.75–1.16) | |
| Male × calendar year (2000–03) | 1.29 | – | – |
| (1.05–1.57) | – | – | |
| Male × calendar year (2004–08) | – | 1.15 | 1.36 |
| – | (1.04–1.28) | (1.17–1.58) | |
| Male × calendar year (2009–14) | – | 1.08 | 0.76 |
| – | (0.92–1.28) | (0.57–1.01) | |
| Weibull shape parameter (p) | 1.90 | 1.79 | 1.75 |
| (1.47–2.45) | (1.47–2.18) | (1.36–2.26) | |
| Subjects | 1,914 | 4,465 | 2,534 |
| Deaths | 349 | 645 | 431 |
1Estimates presented are hazard ratios from a Weibull regression model (with 95 per cent confidence intervals in parentheses). ‘Calendar year’ refers to a per-year relative hazard in the period specified.
2In the pre-ART analysis, the year 2000 is the baseline calendar year.
3In the ART analysis, we use 2000–03 as the baseline calendar year (including all individuals/episodes regardless of ultimate treatment status) for both untreated and treated analyses, and distinguish between untreated or treated episodes only from 2004–14. We do this to model the trend in mortality rates by treatment status from when ART was first introduced in Rakai.
4Reference group is females.
Source: As for Table 1.