Table 2.
OR (95%CI) for the associations between various risk factors and seropositivity for anti-Parietal cell antibodies and different subtypes of upper gastrointestinal cancers in the Linxian General Population Nutrition Intervention Trial
| Variable | OR (95%CI) | Seropositivity for anti-Parietal cell antibodies (>10 units) | ||||
|---|---|---|---|---|---|---|
| Esophageal squamous cell carcinoma | Gastric cardia adenocarcinoma | Gastric non-cardia adenocarcinoma | Upper gastrointestinal cancer | n (%) | OR (95%CI) | |
| Age | 1.02(0.99-1.05) | 1.05(1.03-1.07) | 1.07(1.04-1.09) | 1.05(1.03-1.07) | 137 (15.2) | 1.01(0.99-1.03) |
| <55 years | 1.00 | 1.00 | 1.00 | 1.00 | 78 (15.7) | 1.00 |
| ≥55 years | 1.30 (0.83-2.05) | 1.81 (1.24-2.63) | 2.47 (1.69-3.59) | 1.89 (1.42-2.51) | 59 (14.6) | 0.94 (0.65-1.38) |
| Sex | ||||||
| Female | 1.00 | 1.00 | 1.00 | 1.00 | 73 (16.9) | 1.00 |
| Male | 1.16(0.57-2.38) | 3.19(1.87-5.43) | 2.84(1.64-4.90) | 2.37(1.56-3.60) | 64 (13.7) | 0.77(0.45-1.32) |
| Tobacco smokinga, yes | 0.75(0.34-1.65) | 0.66(0.38-1.14) | 0.94(0.54-1.63) | 0.79(0.51-1.22) | 44 (13.4) | 0.85(0.48-1.51) |
| Alcohol drinkingb, yes | 1.21(0.68-2.14) | 0.80(0.49-1.29) | 0.74(0.47-1.19) | 0.81(0.56-1.16) | 39 (19.0) | 1.79(1.13-2.83) |
| Family history of UGI cancer, yes | 1.38(0.85-2.23) | 1.57(1.06-2.32) | 1.06(0.71-1.59) | 1.34(0.99-1.81) | 48 (16.5) | 1.20(0.81-1.76) |
| Body mass index | 0.96(0.88-1.06) | 0.99(0.92-1.07) | 0.92(0.85-1.00) | 0.96(0.90-1.02) | 137 (15.2) | 1.00(0.93-1.08) |
| H. Pylori CagA seropositivity | 1.03(0.63-1.68) | 2.48(1.59-3.87) | 1.28(0.86-1.91) | 1.58(1.16-2.14) | 92 (16.8) | 1.24(0.82-1.89) |
| PG I/II ratioc | 0.98(0.95-1.01) | 0.95(0.92-0.99) | 0.99(0.97-1.01) | 0.98(0.96-1.00) | 137 (15.2) | 0.98(0.95-1.01) |
| Normal PG I/II ratio | 1.00 | 1.00 | 1.00 | 1.00 | 105 (13.5) | 1.00 |
| Low PG I/II ratio | 1.87 (0.94-3.73) | 1.81 (1.03-3.20) | 3.45 (2.03-5.89) | 2.32 (1.48-3.63) | 32 (25.8) | 2.24 (1.41-3.57) |
Note: Numbers in bold mean that the P value was less than 0.05;
a,
tobacco smoking was defined as ever smoking cigarettes for 6 or more months;
b,
alcohol drinking was defined as any alcoholic beverage consumption in the last 12 months;
c,
PG I/II ratio, pepsinogen I/pepsinogen II ratio, ratio of PG I/II was defined as low for PGI/II ratio ≤4 and normal for PGI/II ratio >4.