Table 4.
OR (95%CI) for the associations between seropositivity for anti-Parietal cell antibodies and esophageal and gastric cancers in the Linxian General Population Nutrition Intervention Trial, stratified by H. pylori infection status and pepsinogen levels
| Group | Cancer type | Case No. | Seropositivity for anti-Parietal cell antibodies (>10 units) |
|
|---|---|---|---|---|
| n (%) | OR(95%CI) | |||
| H. pylori WC−/CagA−a | Control | 101 | 14(13.86) | - |
| UGI cancer | 87 | 10(11.49) | 0.86(0.33-2.23) | |
| ESCC | 15 | 2(13.33) | 0.83(0.14-4.90) | |
| GCA | 31 | 3(9.68) | 0.60(0.13-2.72) | |
| GNCA | 41 | 5(12.20) | 1.08(0.31-3.75) | |
| H. pylori WC+ / CagA−a | Control | 76 | 12(15.79) | - |
| UGI cancer | 87 | 9(10.34) | 0.63(0.23-1.69) | |
| ESCC | 27 | 5(18.52) | 1.35(0.37-4.86) | |
| GCA | 20 | 0 | - | |
| GNCA | 40 | 4(10.00) | 0.44(0.12-1.59) | |
| H. pylori WC+ or WC−/ CagA+ a | Control | 223 | 43(19.28) | - |
| UGI cancer | 326 | 49(15.03) | 0.73(0.45-1.18) | |
| ESCC | 58 | 12(20.69) | 1.08(0.51-2.27) | |
| GCA | 149 | 17(11.41) | 0.48(0.25-0.93) | |
| GNCA | 119 | 20(16.81) | 0.99(0.52-1.87) | |
| Normal PG I/II ratiob | Control | 368 | 56(15.22) | - |
| UGI cancer | 408 | 49(12.01) | 0.70(0.45-1.08) | |
| ESCC | 86 | 14 (16.28) | 1.00(0.52-1.91) | |
| GCA | 169 | 15 (8.88) | 0.45(0.24-0.85) | |
| GNCA | 153 | 20 (13.07) | 0.81(0.46-1.45) | |
| Low PG I/II ratiob | Control | 32 | 13(40.63) | - |
| UGI cancer | 92 | 19(20.65) | 0.72(0.24-2.19) | |
| ESCC | 14 | 5 (35.71) | 4.88(0.23-105.06) | |
| GCA | 31 | 5 (16.13) | 0.42(0.08-2.29) | |
| GNCA | 47 | 9 (19.15) | 0.64(0.16-2.52) | |
Note: ESCC, esophageal squamous cell carcinoma; GCA, gastric cardia adenocarcinoma; GNCA, gastric non-cardia adenocarcinoma; UGI, upper gastrointestinal cancer; Numbers in bold mean that the P value was less than 0.05; We found no evidence for a statistically significant interaction between APCA seropositivity and H. pylori whole cell/ CagA status or pepsinogen levels (p>0.05).
adjusted for age, sex, tobacco smoking, alcohol drinking, body mass index, family history of UGI cancer, and ratio of PG I/II;
adjusted for age, sex, tobacco smoking, alcohol drinking, body mass index, family history of UGI cancer, H. pylori CagA sero-positivity, and ratio of PG I/II.