. Author manuscript; available in PMC: 2020 Jun 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2019 Sep 9;28(12):2022–2029. doi: 10.1158/1055-9965.EPI-19-0512

Table 5.

OR (95%CI) for the associations between serologic profiles of anti-Parietal cell antibodies & pepsinogen I/II ratio and upper gastrointestinal cancers in the Linxian General Population Nutrition Intervention Trial

Disease	Serologic profile^a	Case No.	OR^b	95%CI		P value	P _global
Esophageal squamous cell carcinoma	Normal PG I/II ratio^c	86	1.00
	Low PG I/II ratio^c	14	1.80	0.89	3.65	0.1
	APCA −^d	81	1.00
	APCA +^d	19	1.05	0.58	1.88	0.9

	Normal PG I/II ratio, APCA −	72	1.00				0.1
	Normal PG I/II ratio, APCA +	14	1.05	0.55	2.01	0.9
	Low PG I/II ratio, APCA +	5	1.55	0.52	4.69	0.4
	Low PG I/II ratio, APCA −	9	2.00	0.84	4.75	0.1	0.1

Gastric cardia adenocarcinoma	Normal PG I/II ratio^c	169	1.00
	Low PG I/II ratio^c	31	1.90	1.05	3.43	0.03
	APCA −^d	180	1.00
	APCA +^d	20	0.42	0.24	0.75	0.003

	Normal PG I/II ratio, APCA −	154	1.00
	Normal PG I/II ratio, APCA +	15	0.47	0.25	0.89	0.02
	Low PG I/II ratio, APCA +	5	0.69	0.23	2.10	0.5
	Low PG I/II ratio, APCA −	26	2.06	1.04	4.07	0.04	0.3

Gastric non-cardia adenocarcinoma	Normal PG I/II ratio^c	153	1.00
	Low PG I/II ratio^c	47	3.48	2.02	6.02	<0.0001
	APCA −^d	171	1.00
	APCA +^d	29	0.82	0.50	1.36	0.4

	Normal PG I/II ratio, APCA −	133	1.00
	Normal PG I/II ratio, APCA +	20	0.81	0.45	1.46	0.5
	Low PG I/II ratio, APCA +	9	1.77	0.69	4.55	0.2
	Low PG I/II ratio, APCA −	38	4.13	2.16	7.88	<0.0001	<0.0001

Upper gastrointestinal cancer	Normal PG I/II ratio^c	408	1.00
	Low PG I/II ratio^c	92	2.32	1.46	3.67	0.0004
	APCA −^d	432	1.00
	APCA +^d	68	0.71	0.48	1.05	0.08

	Normal PG I/II ratio, APCA −	359	1.00
	Normal PG I/II ratio, APCA +	49	0.70	0.46	1.08	0.1
	Low PG I/II ratio, APCA +	19	1.26	0.59	2.69	0.5
	Low PG I/II ratio, APCA −	73	2.58	1.47	4.52	0.0009	0.005

Note, APCA, anti-Parietal cell antibodies; PG I/II ratio, pepsinogen I/pepsinogen II ratio; Numbers in bold mean that the P value was less than 0.05;

^a,

APCA sero-positivity was defined as concentration of anti-Parietal cell antibodies ≥10 units; ratio of PG I/II was defined as low for PGI/II ratio ≤4 and normal for PGI/II ratio >4;

^b,

adjusted for age, sex, tobacco smoking, alcohol drinking, body mass index, family history of UGI cancer, H. pylori CagA sero-positivity;

^c,

additionally adjusted for APCA sero-positivity;

^d,

additionally adjusted for PG I/II ratio.