Table 2.
Univariable and multivariable-adjusted odds ratios for developing multiple myeloma among the matched 128 cases and 490 controls.
| Univariable matched analyses | Multivariable matched analyses | |||||
|---|---|---|---|---|---|---|
| Covariate | OR (95% CI) | p-value | aOR (95% CI) | p-value | aOR (95% CI) | p-value |
| 1-y Post-MGUS diagnosis M-protein velocity (g/dL/year) | 2.15 (1.24 to 3.72) | 0.0066 | ||||
| ≤0.1 g/dL/year | 1.00 (referent) | -- | 1.00 (referent) | -- | -- | -- |
| >0.1 g/dL/year | 2.48 (1.71 to 3.60) | <0.0001 | 2.15 (1.37 to 3.35) | 0.0008 | -- | -- |
| Baseline serum M-protein (1 g/dL) | 4.20 (3.01 to 5.83) | <0.0001 | 5.03 (3.46 to 7.33) | <0.0001 | 5.09 (3.50 to 7.40) | <0.0001 |
| Ig isotype | ||||||
| G | 1.00 (referent) | -- | 1.00 (referent) | -- | 1.00 (referent) | -- |
| A | 1.85 (1.15 to 2.98) | 0.0119 | 4.11 (2.25 to 7.52) | <0.0001 | 3.88 (2.14 to 7.03) | <0.0001 |
| BMI group | ||||||
| Normal-weight | 1.00 (referent) | -- | 1.00 (referent) | -- | 1.00 (referent) | -- |
| Overweight | 0.92 (0.54 to 1.56) | 0.7606 | 0.79 (0.42 to 1.47) | 0.4524 | 0.80 (0.43 to 1.50) | 0.4910 |
| Obese | 1.36 (0.80 to 2.32) | 0.2591 | 1.49 (0.79 to 2.84) | 0.2217 | 1.51 (0.80 to 2.85) | 0.2088 |
| Sex | ||||||
| Male | 1.00 (referent) | -- | 1.00 (referent) | -- | 1.00 (referent) | -- |
| Female | 0.69 (0.24 to 1.97) | 0.4915 | 0.34 (0.08 to 1.33) | 0.1202 | 0.38 (0.10 to 1.45) | 0.1555 |
| Comorbidity score | 0.96 (0.90 to 1.03) | 0.2094 | 1.02 (0.94 to 1.11) | 0.6414 | 1.02 (0.94 to 1.11) | 0.5799 |
| Age | 0.99 (0.92 to 1.06) | 0.7454 | 1.00 (0.92 to 1.09) | 0.9925 | 1.00 (0.92 to 1.08) | 0.9464 |
| C-index | 0.8472 | 0.8455 | ||||
Notes: MGUS, monoclonal gammopathy of undetermined significance; OR, odds ratio; aOR, multivariable-adjusted odds ratio; CI, confidence interval; --, reference group, estimate not available