Table 2:
Characteristics of persons with multiple sclerosis and restless legs syndrome based on symptom severity.
| Mild (n = 26) |
Moderate-Very Severe (n = 31) |
p-Value | |
|---|---|---|---|
| Demographic and Clinical Characteristics | |||
| Age (years) | 56.9 (8.6) | 59.4 (11.3) | 0.242# |
| Gender (n (%)) | 19 (73.1) F / 7 (26.9) M | 27 (87.1) F / 4 (12.9) M | 0.182+ |
| MS Type (n (%)) | 0.939+ | ||
| Relapsing-Remitting MS | 17 (65.4) | 21 (67.7) | |
| Secondary Progressive MS | 6 (23.1) | 6 (19.4) | |
| Primary Progressive MS | 3 (11.5) | 4 (12.9) | |
| Disease Duration (years) | 18.8 (9.2) | 19.6 (10.7) | 0.860# |
| Years since symptom onset | 23.7 (10.1) | 26.3 (11.4) | 0.418# |
| PDDS (median [IRQ]) | 3.0 [6.0] | 4.0 [7.0] | 0.093# |
| MS-specific DMT (n (%)) Yes) | 19 (73.1) | 24 (77.4) | 0.704+ |
| IRLS | 6.6 (2.6) | 16.7 (4.8) | 0.000# |
| PSQI | 6.0 (3.7) | 9.2 (4.1) | 0.003# |
| Accelerometer Wear Time (min/day) | 819.6 (83.3) | 799.8 (82.3) | 0.285# |
| Physical Activity Parameters | |||
| LPA (min/day) | 271.9 (66.8) | 240.6 (77.4) | 0.116# |
| MVPA (min/day) | 18.6 (19.0) | 13.6 (19.0) | 0.200# |
| Active Bouts (#/day) | 0.4 (0.6) | 0.3 (0.7) | 0.299# |
| Average Active Bout Length (min) | 5.9 (9.8) | 4.2 (7.5) | 0.267# |
| Total time of Active Bouts (min/day) | 7.9 (12.4) | 5.8 (10.7) | 0.241# |
| Sedentary Behavior Parameters | |||
| Sedentary Behavior (min/day) | 529.1 (58.7) | 545.6 (88.2) | 0.207# |
| Breaks in Sedentary Time (#/day) | 6.5 (1.8) | 7.0 (2.1) | 0.439# |
| Average Sedentary Bout Length (min) | 46.0 (6.6) | 50.8 (11.6) | 0.059# |
| Sedentary Bouts (#/day) | 5.6 (1.9) | 6.2 (2.1) | 0.423# |
| Total time of Sedentary Bouts (min/day) | 258.1 (84.4) | 309.6 (123.4) | 0.120# |
Notes: Nine (12.2%) participants screened positive for RLS and reported no symptoms (IRLS = 0) for the previous seven day period that were not included in this table; values are reported as mean (standard deviation) unless otherwise specified. MS Multiple Sclerosis; PDDS Patient Determined Disease Status; DMT Disease Modifying Therapy; IRLS International Restless Legs Syndrome Study Group Scale; PSQI Pittsburgh Sleep Quality Index; LPA Light Physical Activity; MVPA Moderate-to-vigorous Physical Activity;
Mild and Moderate significantly different;
Mild and Severe-to-Very Severe significantly different;
Moderate and Severe-to-Very Severe significantly different;
Chi Square Analysis;
Mann-Whitney U Test