Table 1.
Grade 1–2 | -----------------------------------------------Grade 3----------------------------------------------- | ||||||
---|---|---|---|---|---|---|---|
Characteristics | All Patients (n=106) | All Patients (n=106) | Group 1: Liver 50/4** Concurrent (n=20) | Group 2: Liver 50/4 Sequential (n=22) | Group 3: Lung 50/4 Concurrent (n=21) | Group 4: Lung 50/4 Sequential (n=24) | Group 5: Liver, Lung, or Adrenal 60/10 Sequential (n=19) |
ALT/AST elevation | 5 (4.7%) | 5 (4.7%) | 1 (0.9%) | 0 | 0 | 1 (0.9%) | 3 (2.8%) |
Bilirubin elevation | – | 2 (1.8%) | 0 | 2 (1.8%) | 0 | 0 | 0 |
Colitis | 1 (0.9%) | 2 (1.8%) | 0 | 1 (0.9%) | 0 | 0 | 1 (0.9%) |
Cholecystitis | – | 1 (0.9%) | 0 | 0 | 0 | 1(0.9%) | 0 |
Diarrhea | 17 (16%) | 6 (5.6%) | 0 | 1 (0.9%) | 0 | 0 | 5 (4.7%) |
Constipation | 2 (1.8%) | 1 (0.9%) | 0 | 0 | 0 | 0 | 1 (0.9%) |
Fatigue | 34 (32%) | 1 (0.9%) | 0 | 1 (0.9%) | 0 | 0 | 0 |
Fever | 6 (5.6%) | 1 (0.9%) | 0 | 0 | 0 | 0 | 1 (0.9%) |
Pain | 13 (12%) | 2 (1.8%) | 0 | 1 (0.9%) | 1 (0.9%) | 0 | 0 |
Pancreatitis/lipase elevation | – | 1 (0.9%) | 1 (0.9%) | 0 | 0 | 0 | 0 |
Pituitary hypophysitis | – | 3 (2.8%) | 0 | 1 (0.9%) | 0 | 1 (0.9%) | 1 (0.9%) |
TSH elevation | 3 (2.8%) | 1 (0.9%) | 0 | 0 | 0 | 1 (0.9%) | 0 |
Pneumonitis | 2 (1.8%) | 1 (0.9%) | 0 | 0 | 0 | 1 (0.9%) | 0 |
Chest pain | – | 1 (0.9%) | 0 | 0 | 1 (0.9%) | 0 | 0 |
Dyspnea | 12 (11%) | 2 (1.8%) | 0 | 0 | 1 (0.9%) | 1 (0.9%) | 0 |
Rash, maculopapular | 32 (30%) | 5 (4.7%) | 0 | 3 (2.8%) | 2 (1.8%) | 0 | 0 |
Upper muscle weakness | 4 (3.7%) | 1 (0.9%) | 0 | 0 | 1 (0.9%) | 0 | 0 |
Sensory neuropathy | 9 (8.5%) | – | – | – | – | – | – |
No patient experienced grade 4 or 5 toxicity probably or definitely related to treatment.
Indicates the radiation dose (in Gy) / number of fractions.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; TSH, thyroid-stimulating hormone.