Table 1.

Toxicity probably or definitely related to radiation or immunotherapy^*

	Grade 1–2	-----------------------------------------------Grade 3-----------------------------------------------
Characteristics	All Patients (n=106)	All Patients (n=106)	Group 1: Liver 50/4** Concurrent (n=20)	Group 2: Liver 50/4 Sequential (n=22)	Group 3: Lung 50/4 Concurrent (n=21)	Group 4: Lung 50/4 Sequential (n=24)	Group 5: Liver, Lung, or Adrenal 60/10 Sequential (n=19)
ALT/AST elevation	5 (4.7%)	5 (4.7%)	1 (0.9%)	0	0	1 (0.9%)	3 (2.8%)
Bilirubin elevation	–	2 (1.8%)	0	2 (1.8%)	0	0	0
Colitis	1 (0.9%)	2 (1.8%)	0	1 (0.9%)	0	0	1 (0.9%)
Cholecystitis	–	1 (0.9%)	0	0	0	1(0.9%)	0
Diarrhea	17 (16%)	6 (5.6%)	0	1 (0.9%)	0	0	5 (4.7%)
Constipation	2 (1.8%)	1 (0.9%)	0	0	0	0	1 (0.9%)
Fatigue	34 (32%)	1 (0.9%)	0	1 (0.9%)	0	0	0
Fever	6 (5.6%)	1 (0.9%)	0	0	0	0	1 (0.9%)
Pain	13 (12%)	2 (1.8%)	0	1 (0.9%)	1 (0.9%)	0	0
Pancreatitis/lipase elevation	–	1 (0.9%)	1 (0.9%)	0	0	0	0
Pituitary hypophysitis	–	3 (2.8%)	0	1 (0.9%)	0	1 (0.9%)	1 (0.9%)
TSH elevation	3 (2.8%)	1 (0.9%)	0	0	0	1 (0.9%)	0
Pneumonitis	2 (1.8%)	1 (0.9%)	0	0	0	1 (0.9%)	0
Chest pain	–	1 (0.9%)	0	0	1 (0.9%)	0	0
Dyspnea	12 (11%)	2 (1.8%)	0	0	1 (0.9%)	1 (0.9%)	0
Rash, maculopapular	32 (30%)	5 (4.7%)	0	3 (2.8%)	2 (1.8%)	0	0
Upper muscle weakness	4 (3.7%)	1 (0.9%)	0	0	1 (0.9%)	0	0
Sensory neuropathy	9 (8.5%)	–	–	–	–	–	–

^*No patient experienced grade 4 or 5 toxicity probably or definitely related to treatment.

^**Indicates the radiation dose (in Gy) / number of fractions.

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; TSH, thyroid-stimulating hormone.