Table 1.

Potential applications of the SynPHARM tool.

SynPHARM used to;	To help build;	For this end application;
	Drug-controlled enzymes	Inducible gene editing. Process control/ parameter passing for synthetic biological biosynthesis systems. Rapid modulation of therapeutic enzymes.
Identify drug-binding sites in proteins that might be transferred as modules to other proteins.	Drug-controlled transcription factors or signal receptors	Process control/parameter passing for synthetic biological biosynthesis systems. Modulation of activities of therapeutic engineered cells. ‘Kill-switches’ for therapeutic engineered cells.
	Drug-binding but otherwise inert proteins	Competitive inhibitors of drugs (eg for overdose).
	Drug-modulated protein interactions	Better pharmacologic targeting of protein-protein interactions (which are traditionally hard to target with small molecules).