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Cytotoxic activity of plocabulin in colon tumor organoids. A, Dose-response curves for plocabulin (blue lines) and SN38 (black lines, (7-Ethyl-10-hydroxy-camptothecin)) in the three CRC–patient-derived organoid cultures. Data are shown as mean ± SEM of independent assays with organoids at different passages. For all assays, Z-score >0.5. B, Overlaid dose-response curves for plocabulin and SN38 (patients #3, #4 and #29) and calculated IC50 values.
