Table 1.
Research activity of extracts of Ganoderma in animal models of diabetes.
| Source | Extract | Experimental Model | Dose | Concentration of Glucose | Reference |
|---|---|---|---|---|---|
| G. lucidum | Water extract of powder of the capsules of G. lucidum contains 95% Ganoderma extract (obtained from the whole fruit body) and 5% dextrin. | C57BL/KsJ mice (female; 6 months old) (normal mice) | 0 g/kg | 168.5 mg/dL | [22] |
| 0.003 g/kg | 161.6 mg/dL | ||||
| 0.03 g/kg | 126.5 mg/dL | ||||
| 0.3 g/kg | 68.5 mg/dL | ||||
| C57BL/KsJ mice (female; 6 months old) (diabetic mice) | 0 g/kg | 668.5 mg/dL | |||
| 0.003 g/kg | 645.9 mg/dL | ||||
| 0.03 g/kg | 441.5 mg/dL | ||||
| 0.3 g/kg | 288,4 mg/dL | ||||
| G. lucidum | Ethanol extract of powdered fruiting bodies | white rats (Rattus norvegicus) derived from Wistar line, male, 2–3 weeks old | 0 mg/kg | 435.75 mg/dL | [23] |
| 250 mg/kg | 312.00 mg/dL | ||||
| 0 mg/kg | 311.00 mg/dL | ||||
| 500 mg/kg | 203.50 mg/dL | ||||
| 0 mg/kg | 384.25 mg/dL | ||||
| 1000 mg/kg | 140.50 mg/dL | ||||
| G. lucidum | Water extract of fruiting bodies | male Wistar rats weighing 85 – 100 g, normal rats | 0 mg/kg | 90 mg/dL | [24] |
| 100 mg/kg | 60 mg/dL | ||||
| 200 mg/kg | 45 mg/dL | ||||
| male Wistar rats weighing 85 – 100 g, diabetic rats | 0 mg/kg | 200 mg/dL | |||
| 100 mg/kg | 150 mg/dL | ||||
| 200 mg/kg | 90 mg/dL | ||||
| G. lucidum | Methanol extract of fruiting bodies | Long-Evans male rats (4 weeks age, weight 83.5 g), induced with alloxan | 0 mg/kg | 14.5 mg/dL | [25] |
| 200 mg/kg | 12.5 mg/dL | ||||
| 400 mg/kg | 12 mg/dL | ||||
| 600 mg/kg | 10 mg/dL | ||||
| 800 mg/kg | 10 mg/dL | ||||
| Petroleum ether extract of fruiting bodies | 0 mg/kg | 14.5 mg/dL | |||
| 200 mg/kg | 10 mg/dL | ||||
| 400 mg/kg | 9.5 mg/dL | ||||
| 600 mg/kg | 7 mg/dL | ||||
| 800 mg/kg | 7 mg/dL | ||||
| Methanol extract of fruiting bodies | Long-Evans male rats (4 weeks age, weight 83.5 g), induced with corticosteroid | 0 mg/kg | 17.5 mg/dL | ||
| 200 mg/kg | 14 mg/dL | ||||
| 400 mg/kg | 12.5 mg/dL | ||||
| 600 mg/kg | 10 mg/dL | ||||
| 800 mg/kg | 9.5 mg/dL | ||||
| Petroleum ether extract of fruiting bodies | 0 mg/kg | 17.5 mg/dL | |||
| 200 mg/kg | 10 mg/dL | ||||
| 400 mg/kg | 7.5 mg/dL | ||||
| 600 mg/kg | 5 mg/dL | ||||
| 800 mg/kg | 4.8 mg/dL | ||||
| G. lucidum | Water extract of fruiting bodies (80%) and alcohol extract of fruiting bodies (20%) | Male Wistar rats aged four weeks and weighing 250 to 300 g | 0 mL/kg | 456 mg/dL | [26] |
| 1 mL/kg | 265 mg/dL |